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KMID : 0861020090240040143
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Korea Journal of Herbology
2009 Volume.24 No. 4 p.143 ~ p.148
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Anxiolytic and Antidepressive Effect of Non-saponin Fraction of Korean Red Ginseng
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Lee Beom-Joon
Kim Jung-Woo
Ji Eun-Young
Yun Seung-Youn
Lee Sang-Myung
Lew Jae-Hwan
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Abstract
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Objectives: Anxiety and depression are stress-related disorders. Their prevalence are increasing rapidly. Ginseng is the root of Panax ginseng C.A. Meyer (Araliaceae) which has been used for many centuries in asian region. Anxiolytic effect is one of the popular effects of ginseng. Several studies reported saponin fraction of ginseng, including ginsenoside, is a major ingredient of anxiolytic effect. In present study, we investigated anxiolytic-like and antidepressant-like effect of non-saponin fraction in mice.
Materials and Method : Mice were divided into five groups. Experimental groups were administered non-saponin fractions (25 mg/kg; nsp25, 50 mg/kg; nsp50, 100 mg/kg; nsp100) respectively once a day in the morning at 9am for 1 week. Then, we performed elevated plus-maze (EPM) test for investigating the anxiolytic-like effect and forced swimming test (FST) for investigating the antidepressant-like action.
Results: Non-saponin fraction 50 mg/kg group increased frequency and time spent (p<0.05) in open arm on EPM test and decreased immobility time (p<0.05) on FST compared with control group.
Conclusions: We suggest that non-saponin fraction has anxiolytic-like effect and antidepressant like effect in mice.
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KEYWORD
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panax ginseng, nonsaponin, anti-anxiety agent, antidepressive agent, elevated plus maze, forced swimming test
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